Dates
General information
Currently, identification of therapeutically valuable natural molecules or design, synthesis and production of their modified analogs is one of the key directions of organic and medicinal chemistry. From this point of view, optically active non-protein amino acids of unusual structure and peptides based on them are of the greatest interest. α-Amino acids containing in the side chain radical variօus rings (heterocyclic, aromatic) and unsaturated bonds that are considered to be aglycones of modern antitumor, hypertensive and other drugs are of special importance among them. The goal of the proposed project is the development of methods for the highly selective asymmetric synthesis of new generation enantiomerically enriched α-amino acids containing variօus rings (heterocyclic, aromatic) and unsaturated bonds in the side chain radical, using square-planar NiII complexes of the Schiff bases with chiral auxiliary 2-[N-(N'-benzylpropyl)amino]benzophenone (BPB) and amino acids and dehydroamino acid. Also, get di- and tri-peptides and glycosylated amino acids based on synthesized amino acids. It is also planned to carry out screening of synthesized amino acids and peptides based on them to reveal their anticancer activities.
