Comparative study of the complex-formation peculiarities of some drugs with serum albumin and nucleic acids

Importance of the studies on interactions of ligands with nucleic acids (NA) and proteins is resulted from the necessity of revelation of molecular mechanisms of influence of drug preparations and biologically active compounds on cell cycling. Moreover, these studies acquire a fundamental value to find out the molecular mechanisms, lying at the basis of the interaction protein-nucleic acid, macromolecule-small molecule, as well as to synthesize new, more efficient drug preparations. The interaction macromolecule-ligand is especially prominent from the point of application of antiviral, antibacterial, antifungal and chemotherapeutic measurements and it lies at the basis of rapid and affordable bio-analytical technologies as well. From this point of view, those ligands become importantly valuable that interact with nucleic acids and this interaction is well-studied. Among such ligands one can mention Hoechst 33258 (H33258), methylene blue (MB), acridine orange (AO) as well as methyl violet (MV). On the account of the aforementioned, we plan to carry out the interaction studies of H33258, AO, MB and MV with NA and serum albumin.