Laboratory of Physics of Macromolecules

In the Research Laboratory of Physics of Macromolecules, research studies on structural transformations of biological macromolecules (DNA, RNA, proteins, biological membranes) under the influence of external factors are implemented by applying theoretical and experimental methods.

The laboratory aims to:

• investigate the physical mechanisms of complex formation of various ligands with biological macromolecules,
• model the structure of the obtained complexes and find the relationship between the structure of the complexes and their biological activity.

The objectives are:

• investigation of the molecular mechanisms of the interaction of pharmacologically active compounds (especially potential anticancer drugs) with DNA, based on the thermodynamic analysis of spectral data,
• investigation of the conditions for the formation of four-stranded G-quadruplex and I-motif structures in the G-rich and C-rich regulatory regions of telomeric DNA,
• study of the effect of radiation on the structure of DNA,
• study of the stability and conductivity of bilayer lipid membranes to various ligands,
• theoretical investigation of the physical properties of methylene nucleic acids in confined space,
• study of the adsorption of ligands on the surface of RNA methylation by application of computer simulation method.